Despite several earlier knowledge reporting an association anywhere between hypertension and the new urinary Na + /K + proportion there are some restrictions to-be believed
At present there is conflicting evidence regarding the potential blood pressure lowering effects of a reduction in urinary Na + /K + excretion. The TAIM randomized control trial in hypertensive participants on a pharmacological intervention reported no significant difference in DBP between the control diet group and a low Na + /high K + diet group during a six month period . A multicenter study by Suppa et al. conducted in hypertensive participants reported a significant reduction in SBP following 4 weeks of modified low sodium high potassium salt intake compared to participants receiving a normal salt intake , yet all participants were receiving a beta blocker, which is not standard first line treatment for hypertension . In addition, a cross-sectional study, the Dallas heart study, which reported an increase in SBP for an increase in the urinary Na + /K + ratio is limited by the modest correlation the use of single morning urine sample . The PURE study reported a strong linear association between estimated Na + /K + ratio and SBP, that was maintained after covariate adjustment, with the greatest SBP observed with the highest estimated K + and lowest estimated K + excretion . Although we observed that a daily K + excretion of <1 g/day is associated with elevated SBP we observed no association between the urinary Na + /K + excretion ratio and SBP at screening or following DASH-dietary intervention in SS or SR participants. In conjunction with the study by Zanetti et al. , our data suggest high Na + and low K + excretion may increase the likelihood of having increased SBP. However, the lack of association between urinary Na + /K + ratio and SBP in our data do not support a urinary Na + /K + molar excretion ratio of 1:1 as a mechanism to lower blood pressure [16, 17].
The current data has several characteristics: (1) The newest Dash -Sodium demo are a very carefully regulated feeding data and you can conformity are constantly tracked, (2) The crossover build getting Na + intervention invited participant’s to help you serve as their control does adultfriendfinder work and reduced inter-person variability, (3) 24-h ambulatory blood pressure level recordings was in fact taken, (4) absence of this new confounding results of antihypertensive mediations, and you may (5) 24-h pee take to range. The top restrict of your own introduce study ‘s the seemingly smaller sample size that provides decreased all of our mathematical capacity to position modest effects of urinary Na + , K + , and you will Na + :K + proportion towards SBP. Once we didn’t observe an imbalance during the baseline features, residual confounding within data is achievable.
Next, the fresh INTERSALT data, and this documented a confident relationship between your urinary Na + /K + proportion and you can blood circulation pressure reported a loss of analytical importance of new relationship into the forty-two of your 52 stores after changes to have covariates together with many years, intercourse and Bmi [thirty two, 33]
To close out the present day data of one’s Dash–Salt Demonstration implies that weight reduction K + supplements isn’t of the down SBP which the latest reductions into the SBP seen pursuing the Dashboard fat loss input taken place by themselves away from a beneficial decrease in the urinary Na + /K + removal proportion aside from brand new salt awareness out of hypertension. Our data do not contain the institution off a-1:step 1 molar removal proportion regarding Na + /K + as blood pressure levels minimizing strategy inside Us Dark colored and non-African Us americans and you can keep the DRI recommendation not to suggest everyday K + intake guidelines. Because of the constraints of your own most recent investigation and also the constant conflict regarding the part off weight loss K + into blood pressure coming very carefully controlled scientific studies are needed to elucidate the possibility perception of diet K + and urinary Na + /K + excretion proportion towards the blood pressure level in both hypertensive and you may normotensive SS and you will SR professionals.